Optimized levels of 1-C nutrients increase the robustness during smoltification through epigenetic gene regulation.
Objective
Studies from both salmon and zebrafish have shown that the 1-C inclusion in the feed determines the growth as well as the overall 1-C nutrients and amino acid compositions in the body. In NutrEpi WP3, we utilise 1-C supplements trough smoltification to analyse the effect of 1-C inclusions on gene expression and DNA methylation patterns.
Experimental design
Triplicate groups were fed with graded levels of 1-C nutrients trough smoltification.
- Low (recommended composition of 1-C nutrients for Atlantic salmon)
- Medium
- High
Publications
Atlantic salmon fed a nutrient package of surplus methionine, vitamin B12, folic acid and vitamin B6 improved growth and reduced the relative liver size, but when in excess growth reduced, Marit Espe, Vibeke Vikeså, Tårn Helgøy Thomsen, Anne‐Catrin Adam, Takaya Saito, Kaja H Skjærven, Aquaculture Nutrition, 2020,
DOI: 10.1111/anu.13010.
The level of 1C diets fed prior to cell isolation affects lipid metabolism in primary liver cells isolated from Atlantic salmon (Salmo salar), Marit Espe, Kaja H Skjærven, Ming Chen, Vibeke Vikeså, Anne‐Catrin Adam, Takaya Saito, Elisabeth Holen, Aquaculture Nutrition, 2020,
DOI: 10.1111/anu.13058.
